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29 January 2008

Mnemonic Series N0. 18: Down Syndrome

Down Syndrome Pathology

DOWN

D - decrease alphafetoprotein and unconjugated estriol
O- one extra chromosome 21
W- women of advanced age
N- nondisjunction during maternal meiosis

Down Syndrome Feature
"My CHILD HAS PROBLEM !"

C- congenital heart disease/cataract
H- hypotonia/hypothyroidism
I- incure fifth finger/increased gap betwwen 1st and 2nd toe
L-leukemia risks x2/lung problem
D-duodenal atresia/delayed development
H- hirschsprund's disease/hearing loss
A- alzheimers disease
S- squint/short neck
P-rotruding tongue/palm crease
R- round face/rolling eye (nystagmus)
O-occiput flat/oblique eye fissure
B- brushfield spot/brachycephaly
L-low nasal bridge/language proeblem
E-epicanthic fold/ear folded
M- mental retardationmyoclonus
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